The Value of White Cell Inflammatory Biomarkers as Potential Predictors for Diabetic Retinopathy in Type 2 Diabetes Mellitus (T2DM)

The pathogenesis of diabetic retinopathy is still challenging, with recent evidence proving the key role inflammation in damage retinal neurovascular unit. This study aims to investigate predictive value neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR), and systemic index (SII) for (DR) its severity. We performed a retrospective on 129 T2DM patients, divided into three groups: without (NDR), non-proliferative DR (NPDR), proliferative (PDR). NLR, MLR, SII were significantly higher PDR group when compared NDR NPDR (3.2 ± 1.6 vs. 2.4 0.9 1.1; p = 0.005; 0.376 0.216 0.269 0.083 0.275 0.111, 0.001; 754.4 514.4 551.5 215.1 560.3 248.6, 0.013, respectively). was correlated serum creatinine (OR: 2.551), NLR 1.645), MPV 1.41), duration diabetes 1.301). Logistic regression analysis identified models very good discrimination power (AUC ROC 0.803, 0.809, 0.830, respectively): combining and, respectively, PLR, MPV, creatinine. SII, LMR associated could be useful integrated comprehensive risk prediction models.